TCJL37
CAS No. : 1258294-34-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $485 | In-stock |
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| 50 mg | Get quote | |
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| Cat. No. : | HY-16640 |
| M.Wt: | 376.74 |
| Formula: | C17H11ClF2N4O2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
TCJL37 is a potent, selective, and orally bioavailable TYK2 inhibitor with a Ki of 1.6 nM. TCJL37 can be used for the research of inflammatory bowel diseases (IBD)[1]. In Vitro: In cell-based assays, TCJL37 (Compound 37) shows IL-12 pSTAT4 EC50 of 224 nM. TCJL37 shows EC50s of 168 nM and 737 nM In human peripheral blood mononuclear cells (PBMC) and human whole blood assay, respectively[1]. In Vivo: TCJL37 exhibits excellent oral exposure in CD-1 mice following oral administration (100 mg/kg). TCJL37 exhibits low clearance (1.0 mL/min/kg) in rat[1].
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Inquiry Information- Product Name:
- TCJL37
- Cat. No.:
- HY-16640
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