BTdCPU
CAS No. : 1257423-87-2
| Size | Price | Stock |
|---|---|---|
| 1mg | $183 | In-stock |
| 5mg | $385 | In-stock |
| 10mg | $605 | In-stock |
| 25mg | $1028 | In-stock |
| 50mg | $1500 | In-stock |
| 100mg | $2100 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-118266 |
| M.Wt: | 339.20 |
| Formula: | C13H8Cl2N4OS |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
BTdCPU is a potent heme regulated inhibitor kinase (HRI) activator that promotes eIF2α phosphorylation and induces apoptosis in Dexamethasone (HY-14648) (Dex)-resistant cancer cells. BTdCPU can be used in the study of cancers such as multiple myeloma and Dex-resistant multiple myeloma[1][2].
IC50 & Target:HRI[1][2].
In Vitro:BTdCPU (10 μM; 4, 8 h) BTdCPU induces phosphorylation of eIF2α and promotes cell death in MM cells[1].
BTdCPU (10 μM; 4, 8 h) shows cytotoxic for dex-resistant primary MM cells with relative sparing of normal cells perhaps[1].
In Vivo:BTdCPU (175 mg/kg; i.p.; single daily for 21 days) inhibits tumor growth without toxicity in mice xenograft breast tumors model[2].
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