Lavendustin A


CAS No. : 125697-92-9

(Synonyms: RG-14355)

125697-92-9
Price and Availability of CAS No. : 125697-92-9
Size Price Stock
1mg $85 In-stock
5mg $178 In-stock
10mg $317 In-stock
25mg $633 In-stock
50mg $1014 In-stock
100mg $1602 In-stock
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Cat. No. : HY-18963
M.Wt: 381.38
Formula: C21H19NO6
Purity: >98 %
Solubility: DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C)
Introduction of 125697-92-9 :

Lavendustin A (RG-14355) is a potent, selective and ATP-competitive inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase, with an IC50 of 11 nM. Lavendustin A does not inhibit protein kinase A or C. Lavendustin A can suppress VEGF-induced angiogenesis[1][2]. IC50 & Target:IC50: 11 nM (EGFR-associated tyrosine kinase)[1] In Vitro:Lavendustin A (5-50μM) dose-dependently inhibits progesterone production in cultures of ovarian dispersates[3]. In Vivo:Lavendustin A (10 μg) reduces the 133Xe clearance of VEGF165-treated (250 ng) sponges and the total fibrovascular growth area[2].

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