CDK4-IN-1
CAS No. : 1256963-02-6
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| Cat. No. : | HY-15612 |
| M.Wt: | 440.97 |
| Formula: | C22H29ClN8 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
CDK4 inhibitor is a novel and specific CDK4/Cyclin D1 inhibitor with an IC50 of 10 nM; 1500 and 500 fold than CDK1/Cyclin B (IC50>15 uM) and CDK2/Cyclin A (IC50=5.265 uM) respectively. IC50 Value: 10 nM (CDK4/Cyclin D1) [1] Target: CDK4 CDK4/6 inhibitor imposed a G1 block on cells at 0.37μM in the CDK4 Cellular Assays. CDK4/6 inhibitor exhibited the most sustained G1 arrest among five compounds and were tested further against a selection of serine-threonine and tyrosine kinases and proved to be selective for CDK4/6 over 35 other kinases [1].
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- Cat. No.:
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