Evolocumab
CAS No. : 1256937-27-5
(Synonyms: AMG 145)
| Size | Price | Stock |
|---|---|---|
| 1mg | $280 | In-stock |
| 5mg | $950 | In-stock |
| 10mg | $1500 | In-stock |
| 25mg | $2400 | In-stock |
| 50mg | $3600 | In-stock |
| 100 mg | Get quote | |
| 200 mg | Get quote | |
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| Cat. No. : | HY-P9930 |
| M.Wt: | 1000.00 |
| Formula: | N/A |
| Purity: | >98 % |
| Solubility: | H2O |
Evolocumab (AMG 145) is a human monoclonal antibody that inhibits PCSK9. Evolocumab is used in the study of hypercholesterolemia and atherosclerotic cardiovascular disease. Evolocumab binds to circulating PCSK9 protein and inhibits its binding to LDLR. Evolocumab has antioxidant and cytoprotective activities against H2O2-induced oxidative damage to endothelial cells. Evolocumab may also negatively regulate activation of the TLR-4/NF-κB signaling pathway to prevent inflammation[1][2][3].
IC50 & Target:PCSK9[1]
In Vitro: Evolocumab (5-100 μg/mL) can significantly prevent the cytotoxicity of H2O2 on human umbilical vein endothelial cells (HUVEC)[2].
Evolocumab (100 μg/mL) can reduce the expression and secretion of inflammatory factors increased by stimulation of rat retinal Müller cells (RMC)[3].
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