Alectinib (Hydrochloride) (Standard)
CAS No. : 1256589-74-8
(Synonyms: CH5424802 (Hydrochloride) (Standard); RO5424802 (Hydrochloride) (Standard); AF-802 (Hydrochloride) (Standard))
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| Cat. No. : | HY-13011AR |
| M.Wt: | 519.08 |
| Formula: | C30H35ClN4O2 |
| Purity: | >98 % |
| Solubility: |
Alectinib (Hydrochloride) (Standard) is the analytical standard of Alectinib (Hydrochloride). This product is intended for research and analytical applications. Alectinib Hydrochloride (CH5424802 Hydrochloride; RO5424802 Hydrochloride; AF-802 Hydrochloride) is a potent, selective, and orally available ALK inhibitor with an IC50 of 1.9 nM and a Kd value of 2.4 nM (in an ATP-competitive manner), and also inhibits ALK F1174L and ALK R1275Q with IC50s of 1 nM and 3.5 nM, respectively[1]. Alectinib demonstrates effective central nervous system (CNS) penetration[2].
IC50 & Target:IC50: 1.9 nM (ALK), 1 nM (ALKF1174L), 3.5 nM (ALKR1275Q)[1]
Kd: 2.4 nM (ALK)[1]
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