PTC299
CAS No. : 1256565-36-2
(Synonyms: Emvododstat)
| Size | Price | Stock |
|---|---|---|
| 1mg | $147 | In-stock |
| 5mg | $310 | In-stock |
| 10mg | $470 | In-stock |
| 25mg | $935 | In-stock |
| 50mg | $1400 | In-stock |
| 100mg | $2250 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-124593 |
| M.Wt: | 467.34 |
| Formula: | C25H20Cl2N2O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
PTC299 is an orally active inhibitor of VEGFA mRNA translation that selectively inhibits VEGF protein synthesis at the post-transcriptional level. PTC299 is also a potent inhibitor of dihydroorotate dehydrogenase (DHODH). PTC299 shows good oral bioavailability and lack of off-target kinase inhibition and myelosuppression. PTC299 can be useful for the research of hematologic malignancies[1][2].
IC50 & Target:VEGF[2]
In Vitro: PTC299 inhibits hypoxia-induced VEGFA protein production in HeLa cells with an EC50 of 1.64 ± 0.83 nM[1].
PTC299 is the most potent inhibitor with an IC50 of about 1 nM, over 10 to 1000-fold more potent than Brequinar, Vidofludimus or A 77-1726 in leukemia cells[1].
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