SAK3
CAS No. : 1256269-87-0
| Size | Price | Stock |
|---|---|---|
| 1mg | $70 | In-stock |
| 5mg | $160 | In-stock |
| 10mg | $260 | In-stock |
| 25mg | $520 | In-stock |
| 50 mg | Get quote | |
| 100 mg | Get quote | |
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| Cat. No. : | HY-120597 |
| M.Wt: | 369.41 |
| Formula: | C20H23N3O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 2 mg/mL (ultrasonic;warming) |
SAK3 is a potent T-type voltage-gated Ca2+ channels (T-VGCCs) enhancer. SAK3 enhances Cav3.1 and Cav3.3 T-type Ca2+ channel currents. Acute SAK3 administration improves memory deficits in olfactory-bulbectomized mice[1]. SAK3 inhibits amyloid β plaque formation in APP-KI mice by activating the proteasome activity[2]. In Vitro: SAK3 (0.01-10 nM) significantly enhances Cav3.1 or Cav3.3 currents in neuro2A cells ectopically expressing Cav3.1 or Cav3.3, respectively[1]. In Vivo: Acute SAK3 (0.5 mg/kg) oral administration promotes acetylcholine (ACh) release in hippocampal CA1 via T-VGCC stimulation via enhancing T-type Ca2+ channel[1].
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