MS-1020
CAS No. : 1255516-86-9
| Size | Price | Stock |
|---|---|---|
| 1mg | $98 | Get quote |
| 5mg | $300 | Get quote |
| 10mg | $485 | Get quote |
| 25mg | $970 | Get quote |
| 50 mg | Get quote | |
| 100 mg | Get quote | |
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| Cat. No. : | HY-123099 |
| M.Wt: | 346.38 |
| Formula: | C21H18N2O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
MS-1020 is a potent and ATP-competitive JAK3 inhibitor. MS-1020 inhibits JAK3/STAT signaling and induces apoptosis. MS-1020 promotes cell death. MS-1020 decreases the expression of tyrosine phosphorylated STAT3 levels. MS-1020 has the potential for the research of cancers harboring aberrant JAK3 signaling[1].
In Vitro: MS-1020 (0-50 µM; 24 h) inhibits STAT92E transcriptional activity in cultured Drosophila cells[1].
MS-1020 (0, 10, 30 , 50 µM) decreases the expression of tyrosine phosphorylated STAT3 levels and shows no changes on total STAT3 levels[1].
MS-1020 (0, 10, 30 , 50 µM; 16 h) decreases the expression of IL-2 (100 ng/ml)-induced STAT5 phosphorylation in Nb2 cells[1].
MS-1020 (0, 10, 30 , 50 µM; 72 h) promotes cell death in a time- and dose-dependent manner in L540 cells[1].
MS-1020 (0, 10, 30 , 50 µM; 72 h) induces apoptosis in L540 cells[1].
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