LY 233053
CAS No. : 125546-04-5
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| Cat. No. : | HY-107710 |
| M.Wt: | 211.22 |
| Formula: | C8H13N5O2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
LY 233053 is a potent and competitive NMDA-receptor antagonist with anticonvulsant and antiepileptic efficacy[1][2]. In Vivo:LY 233053 (0.5 and 5 mg/kg) has no effects on the electroconvulsive threshold but potentiated the anticonvulsant action of all antiepileptics studied[1]. LY 233053 (5 mg/kg) with carbamazepine, diphenylhydantoin, or phenobarbital provides a 50% protection against maximal electroshock, and results in the impairment of long-term memory[1]. LY233053 (intravenous bolus injection;100 mg/kg; administered 5, 30, or 60 minutes after reversible spinal cord ischemia) is effective in limiting ischemic damage, but protection is lost if therapy is not initiated within 60 minutes of injury in New zealand White rabbits[2].
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