Genz-669178
CAS No. : 1254834-91-7
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| Cat. No. : | HY-120462 |
| M.Wt: | 322.38 |
| Formula: | C17H14N4OS |
| Purity: | >98 % |
| Solubility: |
Genz-669178 is an inhibitor for dihydroorotate dehydrogenase (DHODH) with IC50 of 0.015-0.05 μM in Plasmodium spp.. Genz-669178 inhibits P. berghei, P. falciparum strains 3D7 and Dd2 with IC50 of 0.068, 0.008 and 0.01 μM, respectively. Genz-669178 exhibits anti-malarial efficacy in P. berghei-infected mice with ED50 of 13-21 mg/kg/day. Genz-669178 exhibits good pharmacokinetic characteristics in mice[1].
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