BMY 28674
CAS No. : 125481-61-0
(Synonyms: 6-Hydroxybuspirone; 6'-Hydroxybuspirone; BMS 528215)
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| Cat. No. : | HY-100057 |
| M.Wt: | 401.50 |
| Formula: | C21H31N5O3 |
| Purity: | >98 % |
| Solubility: |
BMY 28674 (6-Hydroxybuspirone) is the active metabolite of the anxiolytic buspirone (HY-B1115A) and is metabolized by CYP3A4.4. BMY 28674 binds to the serotonin (5-HT) receptor subtype 5-HT1A in the rat hippocampus and dorsal raphe (EC50s are 4 and 1 μM, respectively) and is an antagonist of dopamine D2, D3, and D4 receptors (IC50s are 3.1, 4.9, and 0.85 μM, respectively). BMY 28674 also inhibits organic cation transporter 1 (OCT1), OCT2, and OCT3 expressing human transporters in S2 proximal tubule cells in a concentration-dependent manner.
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