SSTR5 antagonist 2 (TFA)
CAS No. : 1254733-98-6
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| Cat. No. : | HY-114191A |
| M.Wt: | 660.65 |
| Formula: | C34H36F4N2O7 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
SSTR5 Antagonist 1 (compound 10) is a highly potent, oral active and selective somatostatin (receptor) subtype 5 (SSTR5) antagonist and has potential for the research of treat type 2 diabetes mellitus (T2DM)[1].
IC50 & Target: SSTR5[1].
In Vivo: SSTR5 antagonist 2 (10 mg/kg, orally) increases both total and active circulating incretin hormone GLP1 levels in mice at a dose of 10 mg/kg[1].
SSTR5 antagonist 2 increases pancreatic insulin secretion as well as total and active GLP1 release, and demonstrates synergistic effects in combination with DPP4 inhibitors[1].
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