Mivazerol
CAS No. : 125472-02-8
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| Cat. No. : | HY-106865 |
| M.Wt: | 217.22 |
| Formula: | C11H11N3O2 |
| Purity: | >98 % |
| Solubility: |
Mivazerol is a selective α2-adrenoceptor agonist. Mivazerol decreases the spontaneous release of serotonin (5-HT) and significantly inhibits the immobilization stress-induced enhancement of norepinephrine (NE), dopamine (DA) and dihydroxyphenylacetic acid (DOPAC). Mivazerol inhibits intrathecal release of glutamate evoked by halothane withdrawal in rats, and exerts neuroprotective effects in forebrain ischemia rats. Mivazerol can be used for myocardial ischemia research[1][2][3].
In Vitro:Mivazerol has a α2a-α1 selectivity ratio of 119, and its specificity is between Clonidine (HY-12721) and dexmedetomidine (HY-12719)[3].
In Vivo:Mivazerol (15 μg/kg/h; i.v.; continuous infusion; starting 30 minutes prior to halothane withdrawal) inhibits intrathecal release of glutamate evoked
by halothane withdrawal in rats[1].
Mivazerol (2.5 μg/kg; i.t.; microinjection over 1 minute; 2 minutes prior to halothane withdrawal) inhibits intrathecal release of glutamate evoked
by halothane withdrawal in rats[1].
Mivazerol (10-40 μg/kg; s.c.; single dose; 30 min pre-ischemia) exerts neuroprotective effects in rat forebrain ischemia models[2].
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