GSK2292767
CAS No. : 1254036-66-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $190 | In-stock |
| 10mg | $300 | In-stock |
| 25mg | $640 | In-stock |
| 50 mg | Get quote | |
| 100 mg | Get quote | |
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| Cat. No. : | HY-15280 |
| M.Wt: | 512.58 |
| Formula: | C24H28N6O5S |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic;warming;heat to 60°C) |
GSK2292767 is a potent and selective inhibitor of PI3Kδ, with a pIC50 of 10.1. GSK2292767 showing greater than 500-fold selective over the other PI3K isoforms. GSK2292767 can be used for the research of respiratory disease[1].
IC50 & Target: pIC50: 10.1 (PI3Kδ)[1]
In Vivo: GSK2292767 exhibits high clearance (50 mL/min/kg) in vivo and low oral bioavailability (F < 2%) in a rat PK study[1].
GSK2292767 (0.01-1 μM) has no e?ect on QT interval, Tp?e, or QRS and no signi?cant risk of TdP arrhythmias in a rabbit cardiac ventricular wedge assay[1].
GSK2292767 protects against eosinophil recruitment with an ED50 of 35 μg/kg in the brown Norway rat acute OVA model of Th2 driven in?ammation in the lungs of rats[1].
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