SMU-B
CAS No. : 1253286-90-6
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| Cat. No. : | HY-120387 |
| M.Wt: | 515.41 |
| Formula: | C26H25Cl2FN4O2 |
| Purity: | >98 % |
| Solubility: |
SMU-B is the orally active inhibitor for ALK (IC50<0.5 nM), c-ros oncogene 1 (ROS1), c-MET (IC50=1.87 nM) and AXL (IC50=28.9 nM). SMU-B inhibits the proliferation of MKN45, H1993 and H441 with IC50s of 0.02 μM, 1.58 μM and 2.82 μM, respectively. SMU-B exhibits antitumor efficacy in mouse models[1][2]. IC50 & Target:IC50: <5 nM (ALK); 1.87 nM (c-MET); 28.9 nM (AXL)
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