GB-110
CAS No. : 1252806-70-4
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| Cat. No. : | HY-120528 |
| M.Wt: | 608.77 |
| Formula: | C33H48N6O5 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
GB-110 is a potent, orally active, and nonpeptidic protease activated receptor 2 (PAR2) agonist. GB-110 selectively induces PAR2-mediated intracellular Ca2+ release in HT29 cells with an EC50 of 0.28 μM[1]. IC50 & Target: Protease activated receptor 2[1] In Vitro: In an intracellular Ca2+ (iCa2+) mobilization assay using HT29 colon cancer cells, GB110 (EC50 240±20 nM; pEC50 6.7±0.05) is equipotent with the peptide agonist 2f-LIGRLO-NH2 (EC50 210±30 nM; pEC50 6.6±0.05), 10-fold more potent than SLIGRL-NH2, but ~35-fold less potent than trypsin (EC50 6±0.5 nM; pEC50 8.2±0.8)[2].
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