L-156602
CAS No. : 125228-51-5
(Synonyms: Antibiotic L 156602; PD 124966)
| Size | Price | Stock |
|---|---|---|
| 500μg | $526 | Get quote |
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| Cat. No. : | HY-16384 |
| M.Wt: | 840.96 |
| Formula: | C38H64N8O13 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
L-156602 is a C5a receptor antagonist. L-156602 inhibits inflammation, and the migration of monocytes and neutrophils to the infiltrating site in mouse inflammatory models. L-156602 suppresses the efferent phase of delayed-type hypersensitivity (DTH)[1][2].
IC50 & Target:C5a receptor[1][2]
In Vivo:L-156602 (0.1-0.5 mg/kg, i.p., once daily for 3 days) suppressed inflammation significantly in CDF1 mice induced by Concanavalin A (HY-P2149) and BALB/c mice induced by Muramyl dipeptide (MDP) (HY-127090)[1][2].
L-156602 (0.2-0.5 mg/kg, i.p.) suppressed the infiltration of mononuclear leukocytes and neutrophils into the site of inflammation in PCI-induced inflammation of DBA/1 mice[2].
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