Primidone
CAS No. : 125-33-7
| Size | Price | Stock |
|---|---|---|
| 50mg | $25 | In-stock |
| 100mg | $40 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-B0339 |
| M.Wt: | 218.25 |
| Formula: | C12H14N2O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic);H2O : < 0.1 mg/mL |
Primidone is the orally active inhibitor for TRPM3 (IC50 = 0.6 μM), RIP kinase and voltage-gated sodium channel, and the antagonist for GABA receptor. Primidone can be used as the analgesic and anticonvulsant agent[1][2][3].
In Vitro:Primidone (1-10 μM) reversibly and voltage-independently inhibits TRPM3-mediated Ca2+ influx and current in HEKmTRPM3 cells[1].
Primidone (0-2.5 mM, 8 h) inhibits TNFα-induced necroptosis by inhibiting the binding of RIPK1 to FADD and preventing the formation of cell death complex II[2].
Primidone (1 mM, 8h) inhibits the phosphorylation of RIPK1, RIPK3 and MLKL[2].
In Vivo:Primidone (0.5-10 mg/kg, ip, single dose) inhibits thermal pain and PregS-induced chemical pain, alleviates CFA-induced thermal hyperalgesia in mouse models[1].
Primidone (2.875 mM in drinking water for 5 days) exhibits protective effect in mouse renal ischemia-reperfusion injury (IRI) model[2].
Primidone (6.25 mg/kg, ip, single dose) exhibits anti-inflammatory activity in mouse TNFα-induced systemic inflammatory response syndrome (SIRS) model[2].
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