Hydrocortisone hemisuccinate (sodium)
CAS No. : 125-04-2
(Synonyms: Hydrocortisone 21-hemisuccinate (sodium))
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| Cat. No. : | HY-B1402B |
| M.Wt: | 484.51 |
| Formula: | C25H33NaO8 |
| Purity: | >98 % |
| Solubility: | DMSO : 175 mg/mL (ultrasonic) |
Hydrocortisone hemisuccinate sodium is an orally active physiological glucocorticoid. Hydrocortisone hemisuccinate sodium inhibits proinflammatory cytokine activity, with IC50s of 6.7 and 21.4 μM for IL-6 and IL-3, respectively. Hydrocortisone hemisuccinate sodium can be used for the research of ulcerative colitis (UC)[1].
In Vitro:Hydrocortisone hemisuccinate sodium inhibits IL-6 and IL-3 bioactivity, with IC50s of 6.7 and 21.4 μM, respectively, and shows no cytotoxic effects on IL-6-independent MH60 cells[3].
Hydrocortisone hemisuccinate sodium (0.12-60 μM; 72 h) inhibits phytohemagglutinin (PHA) response in peripheral lymphocytes (PBL) and T-lymphocytes cultures[3].
In Vivo:Hydrocortisone hemisuccinate sodium (30 mg/kg; p.o. twice daily for 5 d) reduces the weight loss and increases the food intake in mice[2].
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