AP 811
CAS No. : 124833-45-0
| Size | Price | Stock |
|---|---|---|
| 1mg | $280 | In-stock |
| 5mg | $720 | In-stock |
| 10mg | $1150 | In-stock |
| 50 mg | Get quote | |
| 100 mg | Get quote | |
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| Cat. No. : | HY-P1419 |
| M.Wt: | 915.09 |
| Formula: | C46H66N12O8 |
| Purity: | >98 % |
| Solubility: | H2O : 1.67 mg/mL (ultrasonic;warming;heat to 25°C) |
AP 811 is a selective atrial natriuretic peptide clearance receptor (ANP-CR, NPR3) antagonist with a Ki of 0.48 nM. AP 811 displays >20000-fold selectivity for NPR3 over NPR1. AP 811 abolishes ANP-induced pump stimulation[1][2]. IC50 & Target:Ki: 0.48 nM (NPR3)[1] In Vitro: In proliferating cardiomyocytes, AP 811 (10-500 nM) could completely abolish the enhanced cardiomyocyte proliferation seen with low concentration ANP (10 nM)[3].
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