Simmitecan (hydrochloride)
CAS No. : 1247847-78-4
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| Cat. No. : | HY-107133 |
| M.Wt: | 635.15 |
| Formula: | C34H39ClN4O6 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Simmitecan hydrochloride, a 9-substituted lipophilic Camptothecin (HY-16560) derivative, is a potent topoisomerase I inhibitor. Simmitecan hydrochloride is an anticancer agent[1][2].
In Vitro:Simmitecan hydrochloride weak inhibitory effects on CYP2D6 (IC50: 32.9 μM) and moderate inhibitory effects on CYP3A4 (IC50: 8.95 μM)[2].
In Vivo:Simmitecan hydrochloride (3.75, 7.5 and 15 mg/kg, i.v. bolus) shows mean elimination half-life t1/2 of approximately 1.4 h in SD rats[2].
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