E-4441

E-4441 is an orally active Antibacterial agent. E-4441 exerts broad-spectrum in vitro antibacterial activity against Gram-positive bacteria and aerobic bacteria. E-4441 exhibits protective effects against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa infections. E-4441 can be used in the research of systemic bacterial infections (Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa infections)^[1]. In Vitro:E-4441 (4 μg/mL) inhibits all anaerobic bacteria^[1].
For 90% of Gram-positive bacterial isolates (Staphylococcus, Streptococcus, and Enterococcus faecalis), the minimum inhibitory concentration (MIC) of E-4441 (18 h) ranges from 0.12 to 1 μg/mL^[1]. In Vivo:E-4441 (serial twofold doses; p.o.; single dose) exhibits in vivo protective activity against systemic Staphylococcus aureus HS-93 infection in mice, with an ED₅₀ of 14.7 mg/kg following a single oral dose^[1].
E-4441 (serial twofold doses; p.o.; single dose) exhibits in vivo protective activity against systemic Escherichia coli HM-42 infection in mice, with an ED₅₀ of 3.0 mg/kg following a single oral dose, identical to the ED₅₀ of ciprofloxacin^[1].
E-4441 (serial twofold doses; p.o.; single dose) exhibits in vivo protective activity against systemic Pseudomonas aeruginosa HS-116 infection in mice, with an ED₅₀ of 71.7 mg/kg following a single oral dose, efficacy comparable to Ciprofloxacin^[1].