MPI-0479605
CAS No. : 1246529-32-7
| Size | Price | Stock |
|---|---|---|
| 2mg | $95 | In-stock |
| 5mg | $160 | In-stock |
| 10mg | $260 | In-stock |
| 50mg | $650 | In-stock |
| 100mg | $890 | In-stock |
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| Cat. No. : | HY-12660 |
| M.Wt: | 407.51 |
| Formula: | C22H29N7O |
| Purity: | >98 % |
| Solubility: | DMSO : 11 mg/mL (ultrasonic;warming) |
MPI-0479605 is a potent and selective ATP-competitive inhibitor of Mps1, with an IC50 of 1.8 nM. IC50 & Target: IC50: 1.8 nM (Mps1)[1] In Vitro: MPI-0479605 is a potent and selective ATP-competitive inhibitor of Mps1, with an IC50 of 1.8 nM. MPI-0479605 (0.1-10 μM) reduces cell viability of HCT-116 cells in a dose-dependent manner. MPI-0479605 shows severe defects in the ability to align chromosomes at the metaphase plate, but causes complete cytokinesis[1]. In Vivo: MPI-0479605 (30 mg/kg daily or 150 mg/kg every fourth day (Q4D), i.p.) inhibits tumor growth by 49% and 74 % in HCT-116 xenografts. However, MPI-0479605 does not show inhibitory activity via daily dosing on the Colo-205 xenografts, and dosing every four days causes 63% tumor growth inhibition (TGI)[1].
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