VU0359595
CAS No. : 1246303-14-9
(Synonyms: CID-53361951; ML-270)
| Size | Price | Stock |
|---|---|---|
| 5mg | $240 | In-stock |
| 10mg | $380 | In-stock |
| 25mg | $650 | In-stock |
| 50mg | $950 | In-stock |
| 100mg | $1300 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-101293 |
| M.Wt: | 497.43 |
| Formula: | C25H29BrN4O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 10 mg/mL (ultrasonic) |
VU0359595 (CID-53361951; ML-270) is a potent and selective pharmacological phospholipase D1 (PLD1) inhibitor with an IC50 of 3.7 nM. VU0359595 is >1700-fold selective for PLD1 over PLD2 (IC50 of 6.4 μM). VU0359595 can be used for the research of cancer, diabetes, neurodegenerative and inflammatory diseases[1][2][3][4].
IC50 & Target:IC50: 3.7 nM (PLD1), 6.4 μM (PLD2)
In Vitro: VU0359595 (5, 50, 500, 5000 nM) inhibits basal and FCS/IGF-1 stimulated proliferation of astroglial cells[2].
VU0359595 (5, 50, 500 nM; 30 min) does not affect basal PLD activity in astrocytes but reduces mitogen-stimulated PLD activity in a concentration-dependent manner[2].
VU0359595 (0.15 μM; 1 h before high glucose treatment and 4 h during high glucose treatment) partially reduces the increase [3H]-phosphatidylethanol (PEth) generation induced by high glucose (33 mM) in retinal pigment epithelium (RPE) cells[3].
VU0359595 (5 μM; 1 h prior to LPS treatment) modulates the autophagic process of LPS-induced (10 μg/ml; 24 h) RPE cells[4].
VU0359595 (2 nM; pretreatment 30 min) blocks the increase of A. fumigatus internalization induced by 50 ng/ml gliotoxin in A549 cells[5].
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