ST3932

ST3932 is a metabolite of ST1535, acts as an antagonist of adenosine A_2A receptor, with K_is of 8 nM and 33 nM for A_2A and A₁ receptors, respectively. IC50 & Target: Ki: 8 nM (A_2A receptor), 33 nM (A₁ receptor)^[1] In Vitro: ST3932 is a metabolite of ST1535, acts as an antagonist of adenosine A_2A receptor, with K_is of 8 nM and 33 nM for A_2A and A₁ receptors, respectively. ST3932 inhibits agonist-induced cAMP accumulation with an IC₅₀ value of 450 nM^[1]. In Vivo: ST3932 (10, 20, 40 mg/kg, p.o.) antagonizes haloperidol-induced catalepsy, and increases motor activity in mice. ST3932 (20, 40 mg/kg, i.p.) significantly increases the number of contralateral turns induced by l-DOPA in rats^[1].