Nerigliatin
CAS No. : 1245603-92-2
(Synonyms: PF-04937319)
| Size | Price | Stock |
|---|---|---|
| 5mg | $110 | In-stock |
| 10mg | $190 | In-stock |
| 25mg | $390 | In-stock |
| 50mg | $710 | In-stock |
| 100mg | $1280 | In-stock |
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| Cat. No. : | HY-108328 |
| M.Wt: | 432.43 |
| Formula: | C22H20N6O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Nerigliatin (PF-04937319) is a orally active glucokinase activator (GKA) with EC50 value of 154.4 μM. Nerigliatin maintains glucose-lowering efficacy. Nerigliatin causes peripheral nerve degeneration. Nerigliatin can be used in type 2 diabetes research.
IC50 & Target:EC50: 154.4 μM (GSA) (PF-04937319)[1]
In Vitro:Nerigliatin (10 μM; 240 min) is metabolized via oxidative (major) and hydrolytic pathways (minor) in rat, dog, and human hepatocytes[3].
In Vivo:Nerigliatin (males: 50-1000 mg/kg; females: 10-1000 mg/kg; p.o.; once daily; 1 month) causes axonal degeneration in the peripheral (sciatic) nerve of female rats[4].
Nerigliatin (5-500 mg/kg; p.o.; once daily; 1 month) leads to peripheral nerve degeneration and unscheduled deaths in dogs[4].
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