Pizuglanstat
CAS No. : 1244967-98-3
(Synonyms: TAS-205 (free base))
| Size | Price | Stock |
|---|---|---|
| 5mg | $55 | In-stock |
| 10mg | $90 | In-stock |
| 25mg | $195 | In-stock |
| 50mg | $285 | In-stock |
| 100mg | $410 | In-stock |
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| Cat. No. : | HY-109134 |
| M.Wt: | 508.61 |
| Formula: | C27H36N6O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 12.5 mg/mL (ultrasonic) |
Pizuglanstat (Compound 3; TAS-205 free base) is an orally active prostaglandin D synthase inhibitor with an IC50 of 76 nM for human hematopoietic prostaglandin D synthase. Pizuglanstat inhibits the synthesis of PGD2. Pizuglanstat improves experimental allergic rhinitis. Pizuglanstat can be used in the study of muscle regenerative diseases such as muscular dystrophy[1][2][3].
In Vitro:Pizuglanstat (10-3000 nM) inhibits PGD2 synthesis in basophilic cells (RBL-2H3 and KU812)[2].
In Vivo:Pizuglanstat (1-60 mg/kg; p.o.; single dose or once daily for 15 days) suppresses late-phase nasal obstruction, eosinophil infiltration, and PGD2 production in nasal lavage fluid in a guinea pig model of experimental allergic rhinitis[2].
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