VU 0364739 (hydrochloride)
CAS No. : 1244640-48-9
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| Cat. No. : | HY-108616 |
| M.Wt: | 482.98 |
| Formula: | C26H28ClFN4O2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
VU 0364739 hydrochloride is a highly selective phospholipase D2 (PLD2) inhibitor with IC50s of 20 and 1500 nM for PLD2 and PLD1, respectively. VU 0364739 hydrochloride induces apoptosis and it can be used for cancer research[1]. In Vitro:VU 0364739 (1, 5 and 10 μM; 24, 48, 72 and 96 hours) time- and dose-dependently decreases cell proliferation of MDA-MB-231 cells under serum-free conditions[1]. VU 0364739 (1, 10 and 100 μM; 48 hours) increases Caspase 3 and 7 activities at a dose of 10 μM[1]. In Vivo:
| Rats IV 1 mg/kg |
Rats PO 10 mg/kg |
|
| CL (mL/min/kg) | 61.5 | |
| t1/2 (h) | 1.52 | |
| Vdss (L/kg) | 8.1 | |
| plasma (ng/mL) | 39.9 | |
| brain (ng/mL) | 29 | |
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