Amylin, amide, rat
CAS No. : 124447-81-0
(Synonyms: Amylin (rat))
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| Cat. No. : | HY-P1464 |
| M.Wt: | 3920.44 |
| Formula: | C167H272N52O53S2 |
| Purity: | >98 % |
| Solubility: | H2O : 100 mg/mL (ultrasonic);DMSO : 50 mg/mL (ultrasonic) |
Amylin, amide, rat is a potent and high affinity ligand of Amylin receptor AMY1 and AMY3 receptors and variably of AMY2 receptors; binding studies are generally used for the latter receptor. IC50 & Target:Amylin receptor AMY1 and AMY3[1] In Vitro: Amylin is an important, but poorly understood, 37 amino acid glucoregulatory hormone with great potential to target metabolic diseases. Amylin is a member of the calcitonin (CT) family of peptides, which includes CT itself, the CGRPs comprising two variants (αCGRP and βCGRP), adrenomedullin (AM) and AM2 (intermedin). Amylin is a centrally acting, neuroendocrine hormone synthesized with insulin in the beta cells of pancreatic islets. Amylin regulates glucose homeostasis by inhibiting gastric emptying, inhibiting the release of the counter-regulatory hormone glucagon and inducing meal-ending satiety. Amylin functions as a glucoregulatory and satiety-inducing hormone, which is protective against postprandial spikes in blood glucose and overeating.[1]
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