Enadoline
CAS No. : 124378-77-4
(Synonyms: CI-977)
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| Cat. No. : | HY-105235 |
| M.Wt: | 396.52 |
| Formula: | C24H32N2O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Enadoline (CI-977) is a highly selective, brain-penetrating, and nonpeptide kappa-opioid receptor (KOR) agonist (Ki=1.25 nM). Antinociceptive effects[1][2]. In Vivo: Enadoline (i.v.; dose of e 15 min before surgery; male Sprague-Dawley rats) dose-dependently (1-100 μg/kg) blocks the development of thermal hyperalgesia as well as static and dynamic allodynia for over 24 h with respective MEDs (minimum effective doses) of < or = 1, 10 and 10 μg/kg[2].
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