GNF-6231
CAS No. : 1243245-18-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $55 | In-stock |
| 10mg | $83 | In-stock |
| 25mg | $150 | In-stock |
| 50mg | $225 | In-stock |
| 100mg | $338 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-100408 |
| M.Wt: | 448.49 |
| Formula: | C24H25FN6O2 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 36 mg/mL |
GNF-6231 is a porcupine (IC50= 0.8 nM), Pron, and endoplasmic reticulum protein inhibitor with oral activity. GNF-6231 has anticancer activity. GNF-6231 can prevent the activation of the Wnt pathway by blocking the secretion of all Wnt ligands. GNF-6231 can be used in the study of myocardial infarction[1][2][3][4].
In Vitro:GNF-6231 inhibits Porcupine enzyme activity with IC50 0.8 nM and isn’t cytotoxic in the concentration range of 20 μM[1].
In Vivo:GNF-6231 (5 mg/kg; Intravenous injection (i.v.); every 24 hours for 6 days) alleviates the symptoms of myocardial infarction in C57Bl/6 mice by inhibiting the activation of the Wnt pathway[1].
GNF-6231 (0.3-3 mg/kg; p.o.; once daily for 2 weeks) shows antitumor activity in a mouse of MMTV-WNT1 xenograft tumor[4].
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