SSTC3


CAS No. : 1242422-09-8

1242422-09-8
Price and Availability of CAS No. : 1242422-09-8
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10mg $480 In-stock
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Cat. No. : HY-120675
M.Wt: 518.53
Formula: C23H17F3N4O3S2
Purity: >98 %
Solubility: DMSO : 125 mg/mL (ultrasonic)
Introduction of 1242422-09-8 :

SSTC3 is a casein kinase 1α (CK1α) activator (Kd = 32 nM) that inhibits WNT signaling (EC50 = 30 nM). SSTC3 exhibits minimal gastrointestinal toxicity compared to other classes of WNT inhibitors[1]. In Vitro: SSTC3 (0-1μM, 5 days) decreases the viability of HCT116 cells in an on-target manner. This capacity is significantly reduced when the mutant CTNNB1 allele driving its carcinogenic properties is deleted[1]. In Vivo: SSTC3 can be maintained for 24 hours after treatment[1].
SSTC3 (25 mg/kg, ip once daily for 8-12 days) suppresses the growth of colorectal carcinoma in CD-1 mice[1].
SSTC3 (10 mg/kg, ip once daily for 1 month) inhibits the growth of Apc mutation-driven tumors[1].

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