1-Caffeoylquinic acid
CAS No. : 1241-87-8
| Size | Price | Stock |
|---|---|---|
| 1mg | $85 | In-stock |
| 5mg | $210 | In-stock |
| 10mg | $340 | In-stock |
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| Cat. No. : | HY-N0460 |
| M.Wt: | 354.31 |
| Formula: | C16H18O9 |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (ultrasonic) |
1-Caffeoylquinic acid is an effective NF-κB inhibitor, shows significant binding affinity to the RH domain of p105 with Ki of 0.007 μM[1]. 1-Caffeoylquinic acid has anti-oxidative stress ability[2]. 1-Caffeoylquinic acid is the Inhibitor for PD-1/PD-L1[3].
IC50 & Target:Ki: 0.007 μM (1-Caffeoylquinic acid)[1]
In Vitro:1-Caffeoylquinic acid blocks the interaction between PD-1 and PD-L1 (IC50=87.28 µM), restores the activity of T cells, and enhances anti-tumor immune response[3].
1-Caffeoylquinic acid is the main phenolic compound that can be isolated from Tetrastigma hemsleyanum leaf. T. hemsleyanum leaf extracts exhibits antioxidant and antiproliferative activities[4].
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