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|---|---|---|
| 100 mg | Get quote | |
| 250 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-113616 |
| M.Wt: | 373.49 |
| Formula: | C21H31N3O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
VU0364572 is a selective allosteric agonist of the M1 muscarinic receptor with an EC50 of 0.11 μM. VU0364572 has neuroprotective potential for preventing memory impairments and reducing neuropathology in Alzheimer’s Disease. VU0364572 is orally active and is CNS penetrant[1][3]. In Vitro:VU0364572 (30 μM; 25 min) promotes KCNQ2, NR1 and MARCKS phosphorylation in striatal/NAc slices[2]. In Vivo:VU0364572 (10 mg/kg/day; oral; 4 months) shows neuroprotective effects in 5XFAD transgenic Alzheimer’s mice. VU0364572 has a half life of 45 minutes[1].
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