SX-576
CAS No. : 1240494-14-7
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| Cat. No. : | HY-124183 |
| M.Wt: | 466.21 |
| Formula: | C20H15BF4N2O4S |
| Purity: | >98 % |
| Solubility: |
SX-576 is a CXCR1 and CXCR2 antagonist with IC50 values of 31 nM and 21 nM, respectively. SX-576 inhibits neutrophil infiltration in a rat model of pulmonary inflammation. SX-576 can be used in studies related to pulmonary inflammation[1].
In Vitro:SX-576 inhibits GROα-mediated intracellular calcium release in isolated human polymorphonuclear leukocytes (PMNs) with an IC50 of 22 ± 3 nM[1].
SX-576 acts as a full antagonist in CXCR2-expressing cells in the PathHunter β-arrestin assay with an IC50 of 130 ± 6 nM[1].
In Vivo:SX-576 (1 mg/kg; i.v.; three doses) potently inhibits ozone-induced pulmonary inflammation in rats, reducing neutrophil influx to near undetectable levels, lowering macrophage counts, and decreasing lung leakage[1].
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