Valecobulin (hydrochloride)
CAS No. : 1240321-53-2
(Synonyms: CKD-516 (hydrochloride))
| Size | Price | Stock |
|---|---|---|
| 5mg | $350 | In-stock |
| 10mg | $550 | In-stock |
| 50mg | $1650 | In-stock |
| 100mg | $2250 | In-stock |
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| Cat. No. : | HY-13598A |
| M.Wt: | 573.06 |
| Formula: | C26H29ClN6O5S |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic);H2O : 50 mg/mL (ultrasonic) |
Valecobulin hydrochloride (CKD-516 hydrochloride) is a valine prodrug of S516 (HY-130233) and a vascular disrupting agent (VDA). Valecobulin hydrochloride is a potent β-tubulin polymerization inhibitor with marked antitumor activity against murine and human solid tumors[1][2]. IC50 & Target: β-tubulin polymerization[1] In Vivo: Valecobulin (5 mg/kg; intraperitoneal injection; administered on days 2, 6, 10, and 14; male BALB/C nu/nu mice) treatment shows markedly antitumor efficacy in various human tumor xenograft models[1].
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