AZD3514
CAS No. : 1240299-33-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $106 | In-stock |
| 10mg | $185 | In-stock |
| 25mg | $315 | In-stock |
| 50mg | $450 | In-stock |
| 100mg | $750 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-16079 |
| M.Wt: | 519.56 |
| Formula: | C25H32F3N7O2 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
AZD3514 is an orally activie and selective androgen receptor (AR) inhibitor. AZD3514 androgen-dependently and -independently inhibits AR signal. AZD351 down-regulates nuclear AR levels in human LNCaP prostate cancer cells in the absence of androgen with an pIC50 value of 5.75. AZD3514 can be used for the research of prostate cancer[1][2][3]. In Vitro: AZD3514 (0-10 μM/L; 7 d) inhibits LNCaP and LAPC4 cells proliferation[2]. AZD3514 (0-10 μM/L; 24 h) inhibits the ligand-driven expression of known AR-regulated genes[2]. AZD3514 (0-30 μM/L; 24 h) reduces AR protein expression in LNCaPs and LAPC4s[2]. AZD3514 (1-10 μM/L; 2 h) reduces AR nuclear translocation in LNCaP cells[2]. In Vivo: AZD3514 (10-100 mg/kg; p.o. once daily for 6 days) inhibits AR signaling in rats[2]. AZD3514 (50 mg/kg; p.o. once daily for 30 days) inhibits prostate tumor growth[2]. AZD3514 (50-100 mg/kg; p.o. once daily for 3 days) significantly reduces nuclear AR protein in vivo[2].
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