Eprinomectin
CAS No. : 123997-26-2
(Synonyms: MK-397)
| Size | Price | Stock |
|---|---|---|
| 50mg | $13 | In-stock |
| 100mg | $16 | In-stock |
| 1g | $64 | In-stock |
| 5g | $194 | In-stock |
| 10g | $324 | In-stock |
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| Cat. No. : | HY-12643 |
| M.Wt: | 1000.00 |
| Formula: | N/A |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
Eprinomectin (MK-397) is a type of avermectin. Eprinomectin, as a broad-spectrum fungicide, has insecticidal, insecticidal and acaricidal activities. Eprinomectin induces apoptosis and autophagy in prostate cancer cells and has antitumor activity[1][2][3].
In Vitro: Eprinomectin (2.5-50 μM; 0-48 h) significantly inhibits DU145 cell viability (IC50: 12.5 µM), colony formation and migration ability, and induces G0/G1 phase cell cycle arrest[1].
Eprinomectin (10-50 μM; 48 h) induces apoptosis and autophagy, increases the production of reactive oxygen species and endoplasmic reticulum stress, and promotes β-catenin nucleoplasmic translocation in DU145 cells[1].
In Vivo: Eprinomectin (0.08-0.5 mg/kg; Local pipette delivery; 14 days) has insecticidal, insecticidal and acaricidal activities in cattle[2].
Pharmacokinetic Analysis in cattle[1]
| Route | Dose (μg/kg) | Kel (day-1) | t1/2 (day) | Tmax (day) | Cmax (ng/mL) | AUC0-t (ng day mL-1) | AUC0-∞ (ng day mL-1) | AUC0-t/AUC0-∞ |
| s.c. | 200 | 0.267 | 2.959 | 1.333 | 47.15 | 228.08 | 240.50 | 0.947 |