UNC0321
CAS No. : 1238673-32-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $116 | In-stock |
| 10mg | $180 | In-stock |
| 25mg | $350 | In-stock |
| 50mg | $550 | In-stock |
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| 200 mg | Get quote | |
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| Cat. No. : | HY-10930 |
| M.Wt: | 515.69 |
| Formula: | C27H45N7O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
UNC0321 is a potent and selective histone methyltransferase G9a inhibitor with a Ki of 63 pM and with assay-dependent IC50 values of 6-9 nM. UNC0321 also inhibits GLP with assay-dependent IC50 values of 15-23 nM. UNC0321 has anti-apoptotic activity and has potential application in diabetic vascular complications[1][3].
In Vitro: UNC0321 (Compound 29) inhibits the activity of G9a ECSD, G9a CLOT, GLP ECSD and GLP CLOT with IC50 values of 9 nM, 6 nM, 15 nM and 23 nM, respectively[1].
UNC0321 (Compound 3) reduces H3K9me2 levels in MDA-MB-231 cells with an IC50 value of 11 μM[2].
UNC0321 (200 pM; 48 h) significantly inhibits the expression of Rab4 in HUVEC[3].
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