Tenofovir (maleate)
CAS No. : 1236287-04-9
(Synonyms: GS 1278 (maleate); PMPA (maleate))
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| Cat. No. : | HY-13910B |
| M.Wt: | 403.28 |
| Formula: | C13H18N5O8P |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Tenofovir maleate (GS 1278 maleate; PMPA maleate) is a nucleotide reverse transcriptase inhibitor to treat HIV and chronic Hepatitis B (HBV)[1].
In Vitro:Tenofovir maleate displays cytotoxicity against HK-2 cells, with IC50 values of 9.21 μM at 48 h and 2.77 μM at 72 h determined by MTT assay. It reduces intracellular ATP levels, elevates oxidative stress and protein carbonylation, and triggers mitochondria-mediated apoptosis in HK-2 cells[1].
Tenofovir maleate formulated with M48U1 in 0.25% HEC inhibits the replication of R5-tropic HIV-1BaL and X4-tropic HIV-1IIIb in activated PBMCs, and suppresses a panel of laboratory HIV-1 strains and patient-derived primary HIV-1 isolates. The combined formulation of Tenofovir maleate and M48U1 in 0.25% HEC delivers synergistic antiretroviral activity against R5-tropic HIV-1BaL infection and exhibits no cytotoxicity toward PBMCs[2].
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