Leucomethylene blue (mesylate)
CAS No. : 1236208-20-0
(Synonyms: TRx0237 (mesylate); Methylene blue leuco base (mesylate))
| Size | Price | Stock |
|---|---|---|
| 5mg | $60 | In-stock |
| 10mg | $90 | In-stock |
| 25mg | $180 | In-stock |
| 50mg | $270 | In-stock |
| 100mg | $420 | In-stock |
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| Cat. No. : | HY-19948 |
| M.Wt: | 477.62 |
| Formula: | C18H27N3O6S3 |
| Purity: | >98 % |
| Solubility: | DMSO : 110 mg/mL (ultrasonic);H2O : 83.33 mg/mL (ultrasonic) |
Leucomethylene blue (TRx0237) mesylate, an orally active second-generation tau protein aggregation inhibitor (Ki of 0.12 μM), could be used for the study of Alzheimer's Disease. Leucomethylene blue mesylate is a common reduced form of Methylene Blue, Methylene Blue is a member of the thiazine class of dyes[1][2][3].
IC50 & Target:Ki: 0.12 μM (tau)[3].
In Vitro: Leucomethylene blue (100 nM, 48 h) mesylate not only decreases the tau and p-tau expression levels, but also reverses the promoting effects of Aβ25-35 on orexin A and adenosine A1R expression levels[2].
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