TUG-469
CAS No. : 1236109-67-3
| Size | Price | Stock |
|---|---|---|
| 5mg | $50 | In-stock |
| 10mg | $80 | In-stock |
| 25mg | $150 | In-stock |
| 50mg | $250 | In-stock |
| 100mg | $400 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-123297 |
| M.Wt: | 345.43 |
| Formula: | C23H23NO2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
TUG-469 is a selective free fatty acid receptor 1 (FFA1/GPR40) agonist with an EC50 value of 19 nM. TUG-469 is >200-fold selective for FFA1 over FFA4. TUG-469 significantly improves glucose tolerance in pre-diabetic mice. TUG-469 can be used for the research of diabetes[1][2]. In Vitro:TUG-469 (0-10 μM) shows efficacy to hFFA1 with a pEC50 value of 7.73[1]. TUG-469 (10 μM) increases the insulin secretion under 10 mM glucose stimulation[1]. TUG-469 (0-100 μM) is >200-fold selective for FFA1 over FFA4 with EC50 values of 19 nM and 4.4 μM for FFA1 and FFA4, respectively[2]. TUG-469 (5 μM; 30 min) significantly increases insulin secretion of INS-1 cells with the presence of high glucose concentration (16.7 mM)[2]. In Vivo:TUG-469 (5 mg/kg; i.p.; 60 and 90 min after glucose administration) affects blood glucose level[2].
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