Peptide YY (PYY) (3-36), Human

Peptide YY (PYY) (3-36), Human is an endogenous appetite-suppressing peptide that acts as a selective agonist of neuropeptide Y (NPY) Y2 receptor. Peptide YY (PYY) (3-36), Human inhibits intestinal fluid secretion, colonic propulsion, and reduces fecal output in mouse models. Peptide YY (PYY) (3-36), Human inhibits dmPGE2-, 5HT (HY-B1473A)-, and Castor oil (HY-107799)-induced diarrhea in mice. Peptide YY (PYY) (3-36), Human improves metabolic parameters and mitochondrial function in obese rat MASLD models. Peptide YY (PYY) (3-36), Human can be used for research on intestinal diseases such as diarrhea and metabolic dysfunction-associated steatotic liver disease^[1][2]. In Vivo:Peptide YY (PYY) (3-36), Human (0.01-1 mg/kg; i.p.; single dose) dose-dependently inhibits dmPGE₂-, 5HT (HY-B1473A)-, and (Castor oil) HY-107799-induced diarrhea in mice^[1].
Peptide YY (PYY) (3-36), Human (1 mg/kg; i.p.; single dose) significantly blocks dmPGE₂-induced intestinal fluid accumulation in mice^[1].
Peptide YY (PYY) (3-36), Human (0.01-1 mg/kg; i.p.; single dose) dose-dependently reduces normal fecal output in mice and increases colonic bead expulsion time in mice, indicating inhibition of colonic propulsion^[1].
Peptide YY (PYY) (3-36), Human (0.015 mol/kg/day; osmotic minipump; continuous; 8 weeks) improves metabolic parameters (HOMA index) and mitochondrial function without reducing body weight in an early MASLD rat model, and significantly decreases mitochondrial respiration and PPAR/MCAD protein expression^[2].