DS-5272
CAS No. : 1235575-97-9
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| 5mg | $1582 | Get quote |
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| Cat. No. : | HY-120667 |
| M.Wt: | 703.67 |
| Formula: | C34H38Cl2F2N6O2S |
| Purity: | >98 % |
| Solubility: |
DS-5272 is an orally acitve inhibitor for p53-MDM2 with an IC50 of 20 nM. DS-5272 inhibits the proliferation of SJSA-1 (wildtype p53, IC50=0.17 μM) and DLD-1 (mutant p53). DS-5272 arrest the cell cycle, and induces apoptosis in SJSA-1. DS-5272 exhibits antitumor efficacy in mice[1]. IC50 & Target:IC50: 20 nM (p53-MDM2 interaction)
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