PF-05198007
CAS No. : 1235406-19-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $185 | In-stock |
| 10mg | $250 | In-stock |
| 25mg | $395 | In-stock |
| 50mg | $610 | In-stock |
| 100mg | $965 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-12883A |
| M.Wt: | 533.91 |
| Formula: | C19H12ClF4N5O3S2 |
| Purity: | >98 % |
| Solubility: | DMSO : 150 mg/mL (ultrasonic) |
PF-05198007 is a potent, orally active and selective arylsulfonamide Nav1.7 inhibitor. PF-05198007 is a compound with a similar pharmacodynamic profile to PF-05089771[1][2]. IC50 & Target:Nav1.7[1]. In Vitro: PF-05198007 (30 nM) blocks on average 83.0 ± 2.7% of the total TTX-S current indicating that the major TTX-S conductance is carried through Nav1.7 channels in small-diameter mouse DRG neurons (n = 35)[1]. In Vivo: PF-05198007 (1 or 10 mg/kg, orally) reduces the capsaicin flare response in WT, but not Nav1.7Nav1.8Cre mice[1].
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