Bcl-xL antagonist 2
CAS No. : 1235032-75-3
| Size | Price | Stock |
|---|---|---|
| 5mg | $370 | In-stock |
| 10mg | $555 | In-stock |
| 25mg | $999 | In-stock |
| 50mg | $1398 | In-stock |
| 100mg | $1820 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-12908 |
| M.Wt: | 436.51 |
| Formula: | C21H16N4O3S2 |
| Purity: | >98 % |
| Solubility: | DMSO : 62.5 mg/mL (ultrasonic) |
Bcl-xL antagonist 2 is a potent, selective, and orally active antagonist of BCL-XL with an IC50 and Ki of 0.091 μM and 65 nM, respectively. Bcl-xL antagonist 2 promotes the apoptosis of cancer cells. Bcl-xL antagonist 2 has the potential for the research of the chronic lymphocytic leukemia (CLL) and non-Hodgkin’s lymphoma (NHL)[1][2].
IC50 & Target: 0.091 μM (BCL-XL)[1]
In Vivo: Assessment of Pharmacokinetics (PK) profile of Bcl-xL antagonist 2 (compound 14) in rat[1].
| iv (1 mg/kg) | po (5 mg/kg) | ||
| CLp (mL/min/kg) | Vss (L/kg) | t 1/2 (h) | F % |
| 0.47 | 0.16 | 6.0 | 16 |
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