XMD8-92
CAS No. : 1234480-50-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $62 | In-stock |
| 10mg | $87 | In-stock |
| 25mg | $190 | In-stock |
| 50mg | $300 | In-stock |
| 100mg | $500 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-14443 |
| M.Wt: | 474.55 |
| Formula: | C26H30N6O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
XMD8-92 is a potent ERK5 (BMK1)/BRD4 inhibitor with Kds of 80 and 190 nM, respectively. XMD8-92 inhibits DCAMKL2, PLK4 and TNK1 with Kds of 190, 600 and 890 nM, respectively. Anti-cancer activity[1][2].
IC50 & Target: Kd: 80 nM (ERK5/BMK1)[1]
In Vitro: XMD8-92 (0-5 Μm; 48 hours) inhibits the proliferation of HMEC and cancer cells[1].
XMD8-92 effectively inhibits BMK1 activation as well as induces PML’s (promyelocytic leukemia protein) downstream effector, p21. XMD8-92 significantly inhibits basic fibroblast growth factor (bFGF) induced angiogenesis in Matrigel plugs. XMD8-92 significantly induces p21 expression in HeLa and A549 cells[1].
In Vivo: XMD8-92 (i.p.; twice a day for 28 days) significantly inhibits the growth of the xenografted human tumors[1].
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