Ex26
CAS No. : 1233332-37-0
(Synonyms: S1P1-IN-Ex26)
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| Cat. No. : | HY-117213 |
| M.Wt: | 494.98 |
| Formula: | C28H28ClFN2O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Ex26 (S1P1-IN-Ex26) is a potent and selective sphingosine 1-phosphate receptor 1 (S1P1) antagonist (IC50=0.93 nM). Ex26 shows >3,000-fold selectivity for S1P1 over other Sphingosine 1-phosphate receptors. Ex26 can be used in experimental autoimmune encephalomyelitis reseach[1].
IC50 & Target:IC50: 0.93 nM (S1P1)[1]
In Vitro:Ex26 (0-10 μM; 1 h) treatment shows excellent selectivity for S1P1 over other Sphingosine 1-phosphate receptors[1].
In Vivo:Ex26 (i.p.; 3 mg/kg; once daily; 3 d) treatment disrupts S1P1 signaling inhibiting the lymphocyte and thymocyte egress[1].
Ex26 (i.p.; 30 mg/kg; once daily; 15 d) treatment alleviates experimental autoimmune encephalomyelitis by S1P1 antagonism[1].
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