Aladorian (sodium)

Aladorian (ARM036; S44121) sodium is a non-peptidic ryanodine receptor 2 (RyR2) stabilizer. Aladorian sodium stabilizes RyR2 channels and rectifies abnormal Ca²⁺ handling in cardiomyocytes. Aladorian sodium improves cardiomyocyte Ca²⁺ homeostasis independent of dystrophin restoration. Aladorian sodium attenuates early cardiomyopathy and enhances left ventricular function in a canine muscular dystrophy model. Aladorian sodium can be used for the research of heart failure, Duchenne muscular dystrophy-associated cardiomyopathy and muscular dystrophy^[1][2][3]. In Vitro:Aladorian (ARM036) sodium produces a characteristic product ion mass spectrum when analyzed via high resolution/high accuracy mass spectrometry at a collision energy of 25 eV, with its protonated molecular ion detected at m/z 268.0639^[5]. In Vivo:Aladorian (ARM036) (4 months) sodium alleviates early cardiomyopathy in juvenile golden retrievers with golden retriever muscle dystrophy, improving left ventricular longitudinal strain and normalizing RyR2 channel closed state probability and calcium handling^[2].